Although I have spoken to him many times, he never took any ________ of what I said.

A.remark

B.attention

C.notice

D.observation

答案及解析： C

解析：

固定搭配。take notice of(vt.)注意到，留心到(通常用于否定句)。如：Take no notice of what others say about your way of life.(别理会别人怎么评价你的生活方式。)