As Jane was ill, I was asked to ________ the whole class instead of her.

A.in charge of

B.under the charge of

C.take charge of

D.have a charge of

答案及解析： C

解析：

题意：简病了，所以我被要求代替她来掌管整个班级。take charge of为固定搭配，意为"掌管，控制"。in charge of为介词短语；

under the charge of"在……的控制下"；

D项中多了冠词。